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เรื่องราวของ โมเสส (ชาร์ลตัน เฮสตัน) ชายผู้รู้ความจริงว่ามีเลือดทาสเต็มตัว และสละทุกสิ่งเพื่อหาทางปลดปล่อยทาสฮีบรูให้เป็นไท

To escape the edict of Egypt's Pharoah, Rameses I, condemning all first-born Hebrew males, the infant Moses (Charlton Heston) is set adrift on the Nile in a reed basket. Saved by the pharaoh's daughter Bithiah, he is adopted by her and brought up in the court of her brother, Pharaoh Seti.Moses gains Seti's favor and the love of the throne princess Nefertiri, as well as the hatred of Seti's son, Rameses.

When his Hebrew heritage is revealed, Moses is cast out of Egypt, and makes his way across the desert where he marries, has a son and is commanded by God to return to Egypt to free the Hebrews from slavery. In Egypt Moses's fiercest enemy proves to be not Rameses, but someone near to him who can harden his heart.